Ọrịa akụrụ na-adịghị ala ala (CKD) na-enwekarị hyperphosphatemia, hyperphosphatemia na-adịte aka nwere ike ịkpata nsogbu siri ike dị ka hyperparathyroidism nke abụọ, osteodystrophy gbasara akụrụ, na ọrịa obi. Ịchịkwa ọkwa phosphorus dị n'ọbara bụ akụkụ dị mkpa nke njikwa ndị ọrịa CKD, na phosphate binders bụ ọgwụ nkuku maka ọgwụgwọ hyperphosphatemia. N'afọ adịbeghị anya,lanthanum carbonate, dị ka ụdị ọhụrụ nke na-abụghị calcium na aluminom phosphate binder, ejirila nwayọọ nwayọọ banye n'ọhịa nke ndị mmadụ wee malite "asọmpi" na omenala phosphate binders.
"Ezigbo" na "demerits" nke ndị na-ekekọta phosphate omenala
Ngwakọta phosphate ọdịnala na-agụnyekarị ihe nkedo phosphate nwere calcium (dị ka calcium carbonate na calcium acetate) na aluminom nwere phosphate binders (dị ka aluminom hydroxide). Ha na-ejikọta ya na phosphates na nri na-emepụta ogige ndị na-adịghị edozi, si otú ahụ na-ebelata mmịnye nke eriri afọ nke phosphorus.
Calcium nwere phosphate binders: ọnụ ala dị ala na mmetụta mbelata phosphorus doro anya, mana iji ogologo oge mee ihe nwere ike ibute hypercalcemia ma bulie ohere nke ịgbatị akwara vaskụla.
Aluminom nwere phosphorus binders: Mmetụta mbelata phosphorus siri ike, mana mkpokọta aluminom na-egbu egbu nke ukwuu ma nwee ike ibute ọrịa ọkpụkpụ metụtara aluminom na ọrịa encephalopathy, ma ọ naghị eji ya ugbu a.
Lanthanum carbonate: Onye bịara ọhụrụ na-ebili, nwere uru ndị a ma ama
Lanthanum carbonate bụ carbonate nke ụwa metal metal lanthanum na-adịghị ahụkebe, nwere usoro ejikọ phosphorus pụrụ iche. Ọ na-ahapụ ion lanthanum na gburugburu acidic nke tract digestive ma mepụta lanthanum phosphate na phosphate nke na-adịghị edozi ahụ nke ukwuu, si otú a na-egbochi nnabata nke phosphorus.
Ntinye nkenke nke lanthanum carbonate
| Aha ngwaahịa | Lanthanum carbonate |
| Usoro | La2 (CO3) 3.xH2O |
| CAS Mba. | 6487-39-4 |
| Ibu molekụla | 457.85 (nke ọma) |
| Njupụta | 2.6 g/cm3 |
| Ebe mgbaze | N/A |
| Ọdịdị | kristal ọcha ntụ ntụ |
| Solubility | Soluble na mmiri, moderately soluble na siri ike ịnweta acid |
| Nkwụsi ike | Dị mfe hygroscopic |
E jiri ya tụnyere ndị na-ekekọta phosphorus ọdịnala, lanthanum carbonate nwere uru ndị a:
Enweghị calcium na aluminom, nchekwa dị elu: Zere ihe ize ndụ nke hypercalcemia na nsị aluminom, karịsịa maka ndị ọrịa nwere ọgwụgwọ ogologo oge na ihe ize ndụ nke calcification vaskụla.
Ike ijikọ phosphorus siri ike, mmetụta mbelata phosphorus dị ịrịba ama: Lanthanum carbonate nwere ike jikọta phosphorus nke ọma n'ọtụtụ pH, yana ike njide ya siri ike karịa ihe ejikọtara phosphorus ọdịnala.
Mmeghachi omume ọjọọ nke eriri afọ ole na ole, ezigbo nnabata onye ọrịa: Lanthanum carbonate na-atọ ụtọ nke ukwuu, ọ dị mfe ịnara, enwechaghị mgbakasị eriri afọ, yana ndị ọrịa nwere ike na-agbaso ọgwụgwọ ogologo oge.
Ihe akaebe nyocha ụlọ ọgwụ: Lanthanum carbonate na-arụ ọrụ nke ọma
Ọtụtụ ọmụmụ ụlọ ọgwụ akwadola ịdị irè na nchekwa nke lanthanum carbonate na ndị ọrịa CKD. Nnyocha e mere egosiwo na lanthanum carbonate adịghị ala ma ọ bụ ọbụna karịa ihe ndị na-ejikọta phosphate omenala na ibelata ọkwa phosphorus ọbara, ma nwee ike ịchịkwa ọkwa iPTH nke ọma ma melite ihe ngosi nke ọkpụkpụ. Tụkwasị na nke ahụ, nchekwa nke ọgwụgwọ ogologo oge na lanthanum carbonate dị mma, ọ dịghịkwa nchịkọta lanthanum doro anya na mmeghachi omume na-egbu egbu ahụbeghị.
Ọgwụgwọ onwe onye: Họrọ atụmatụ kacha mma maka onye ọrịa
Ọ bụ ezie na lanthanum carbonate nwere ọtụtụ uru, ọ pụtaghị na ọ nwere ike dochie kpamkpam phosphate binders. Ọgwụ ọ bụla nwere ihe ngosi ya na contraindications, yana atụmatụ ọgwụgwọ kwesịrị ịdị n'otu n'otu dabere na ọnọdụ onye ọrịa ahụ akọwapụtara.
Lanthanum carbonate dabara adaba maka ndị ọrịa ndị a:
Ndị ọrịa nwere hypercalcemia ma ọ bụ ihe ize ndụ nke hypercalcemia
Ndị na-arịa ọrịa vascular calcification ma ọ bụ ihe ize ndụ nke calcification vaskụla
Ndị ọrịa nwere ndidi na-adịghị mma ma ọ bụ adịghị arụ ọrụ nke ihe nkedo phosphate ọdịnala
A ka nwere ike iji ihe nkedo phosphate ọdịnala maka ndị ọrịa ndị a:
Ndị ọrịa nwere oke ọnọdụ akụ na ụba
Ndị ọrịa na-enwe nfụkasị ma ọ bụ na-anabataghị lanthanum carbonate
Na-ele anya n'ọdịnihu: Lanthanum carbonate nwere ọdịnihu dị mma
Site n'ịbawanye nyocha nke ụlọ ọgwụ na nchịkọta nke ahụmahụ ahụike, ọnọdụ nke lanthanum carbonate na ọgwụgwọ hyperphosphatemia na ndị ọrịa CKD ga-aga n'ihu na-akawanye mma. N'ọdịnihu, a na-atụ anya ka carbonate lanthanum ga-abụ eriri phosphate nke mbụ, na-ewetara ndị ọrịa CKD ozi ọma.
Oge nzipu: Mar-25-2025